| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APOA5 (207-366) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APOA5 |
| Gene ID: |
116519 |
| Uniprot ID: |
APOA5_HUMAN |
| Immunogen Region: |
207-366 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 207-366 of human APOA5 (NP_443200.2). |
| Immunogen Sequence: |
QELHRSVAPHAPASPARLSR CVQVLSRKLTLKAKALHARI QQNLDQLREELSRAFAGTGT EEGAGPDPQMLSEEVRQRLQ AFRQDTYLQIAAFTRAIDQE TEEVQQQLAPPPPGHSAFAP EFQQTDSGKVLSKLQARLDD LWEDITHSLHDQGHSHLGDP |
| Tissue Specificity | Liver and plasma. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin. |
| Protein Name | Apolipoprotein A-VApo-AvApoa-VApolipoprotein A5Regeneration-Associated Protein 3 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-8963889Reactome: R-HSA-8963901 |
| Cellular Localisation | SecretedEarly EndosomeLate EndosomeGolgi ApparatusTrans-Golgi NetworkIn The Presence Of Sorl1Internalized To Early EndosomesSorted In A Retrograde Fashion To Late EndosomesFrom Which A Portion Is Sent To Lysosomes And DegradationAnother Portion Is Sorted To The Trans-Golgi Network |
| Alternative Antibody Names | Anti-Apolipoprotein A-V antibodyAnti-Apo-Av antibodyAnti-Apoa-V antibodyAnti-Apolipoprotein A5 antibodyAnti-Regeneration-Associated Protein 3 antibodyAnti-APOA5 antibodyAnti-RAP3 antibodyAnti-UNQ411 antibodyAnti-PRO773 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
