| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-APLP2 (370-580) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
APLP2 |
| Gene ID: |
334 |
| Uniprot ID: |
APLP2_HUMAN |
| Immunogen Region: |
370-580 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 370-580 of human APLP2 (NP_001633.1). |
| Immunogen Sequence: |
PTNDVDVYFETSADDNEHAR FQKAKEQLEIRHRNRMDRVK KEWEEAELQAKNLPKAERQT LIQHFQAMVKALEKEAASEK QQLVETHLARVEAMLNDRRR MALENYLAALQSDPPRPHRI LQALRRYVRAENKDRLHTIR HYQHVLAVDPEKAAQMKSQV MTHLHVIEERRNQSLSLLYK VPYVAQEIQEEIDELLQEQR ADMDQFTASIS |
| Tissue Specificity | Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues. |
| Post Translational Modifications | The BPTI/Kunitz inhibitor domain is O-glycosylated. |
| Function | May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. |
| Protein Name | Amyloid Beta Precursor Like Protein 2ApphAmyloid BetaA4 Precursor-Like Protein 2Amyloid Protein HomologAmyloid-Like Protein 2Aplp-2Cdei Box-Binding ProteinCdebpSperm Membrane Protein Ywk-Ii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinNucleus |
| Alternative Antibody Names | Anti-Amyloid Beta Precursor Like Protein 2 antibodyAnti-Apph antibodyAnti-Amyloid Beta antibodyAnti-A4 Precursor-Like Protein 2 antibodyAnti-Amyloid Protein Homolog antibodyAnti-Amyloid-Like Protein 2 antibodyAnti-Aplp-2 antibodyAnti-Cdei Box-Binding Protein antibodyAnti-Cdebp antibodyAnti-Sperm Membrane Protein Ywk-Ii antibodyAnti-APLP2 antibodyAnti-APPL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
