Anti-APAF1 antibody [R03-8A3] (STJA0035853)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human APAF1
General Information
| Short Description | Rabbit monoclonal anti-APAF1 for use in WB, IHC-P, ICC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-8A3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | APAF1 |
| Gene ID | 317 |
| Uniprot ID | APAF_HUMAN |
| Immunogen | A synthesized peptide derived from human APAF1 |
Additional Info
| Tissue Specificity | Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. |
| Function | Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. |
| Protein Name | Apoptotic Protease-Activating Factor 1Apaf-1 |
| Database Links | Reactome: R-HSA-111458Reactome: R-HSA-111459Reactome: R-HSA-111463Reactome: R-HSA-111464Reactome: R-HSA-6798695Reactome: R-HSA-6803207Reactome: R-HSA-8953750Reactome: R-HSA-9627069 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Apoptotic Protease-Activating Factor 1 antibodyAnti-Apaf-1 antibodyAnti-APAF1 antibodyAnti-KIAA0413 antibody |
Information sourced from Uniprot.org