Anti-AOC3 antibody (27-190) (STJ22624)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AOC3 (27-190) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AOC3 |
| Gene ID | 8639 |
| Uniprot ID | AOC3_HUMAN |
| Immunogen Region | 27-190 |
| Immunogen Sequence | GRGGDGGEPSQLPHCPSVSP SAQPWTHPGQSQLFADLSRE ELTAVMRFLTQRLGPGLVDA AQARPSDNCVFSVELQLPPK AAALAHLDRGSPPPAREALA IVFFGRQPQPNVSELVVGPL PHPSYMRDVTVERHGGPLPY HRRPVLFQEYLDIDQMIFNR ELPQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 27-190 of human AOC3 (NP_003725.1). |
Additional Info
| Tissue Specificity | Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. |
| Post Translational Modifications | Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. N- and O-glycosylated. |
| Function | Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine. Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Isoform 2: Has no semicarbazide-sensitive amine oxidase (SSAO) activity. |
| Protein Name | Amine Oxidase Copper-Containing 3Amine Oxidase Copper-Containing 3Copper Amine OxidaseHpaoSemicarbazide-Sensitive Amine OxidaseSsaoVascular Adhesion Protein 1Vap-1 |
| Database Links | Reactome: R-HSA-211945 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Amine Oxidase Copper-Containing 3 antibodyAnti-Amine Oxidase Copper-Containing 3 antibodyAnti-Copper Amine Oxidase antibodyAnti-Hpao antibodyAnti-Semicarbazide-Sensitive Amine Oxidase antibodyAnti-Ssao antibodyAnti-Vascular Adhesion Protein 1 antibodyAnti-Vap-1 antibodyAnti-AOC3 antibodyAnti-VAP1 antibody |
Information sourced from Uniprot.org