Anti-ANXA13 antibody (1-316) (STJ115681)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ANXA13 (1-316) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANXA13 |
| Gene ID | 312 |
| Uniprot ID | ANX13_HUMAN |
| Immunogen Region | 1-316 |
| Immunogen Sequence | MGNRHAKASSPQGFDVDRDA KKLNKACKGMGTNEAAIIEI LSGRTSDERQQIKQKYKATY GKELEEVLKSELSGNFEKTA LALLDRPSEYAARQLQKAMK GLGTDESVLIEVLCTRTNKE IIAIKEAYQRLFDRSLESDV KGDTSGNLKKILVSLLQANR NEGDDVDKDLAGQDAKDLYD AGEGRWGTDELAFNEVLAKR SYKQLRATFQAYQILIGKDI EEAIEEETSGDLQKAYLTL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human ANXA13 (NP_004297.2). |
Additional Info
| Tissue Specificity | Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum. |
| Function | Isoform A: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner. Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup. Isoform B: Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium. |
| Protein Name | Annexin A13Annexin XiiiAnnexin-13Intestine-Specific AnnexinIsa |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneCell MembraneLipid-AnchorCytoplasmic VesicleMyristoylation Anchors The Protein To The MembraneBut The Protein Also Displays Calcium-DependentReversible Binding To Lipid MembranesAssociated With The Plasma Membrane Of UndifferentiatedProliferating Crypt Epithelial Cells As Well As Differentiated Villus Enterocytes |
| Alternative Antibody Names | Anti-Annexin A13 antibodyAnti-Annexin Xiii antibodyAnti-Annexin-13 antibodyAnti-Intestine-Specific Annexin antibodyAnti-Isa antibodyAnti-ANXA13 antibodyAnti-ANX13 antibody |
Information sourced from Uniprot.org