| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ANXA11 |
| Gene ID: | 311 |
| Uniprot ID: | ANX11_HUMAN |
| Immunogen Region: | 276-505 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 276-505 of human Annexin A11 (NP_001148.1). |
| Immunogen Sequence: | FDIYEIKEAIKGVGTDEACL IEILASRSNEHIRELNRAYK AEFKKTLEEAIRSDTSGHFQ RLLISLSQGNRDESTNVDMS LAQRDAQELYAAGENRLGTD ESKFNAVLCSRSRAHLVAVF NEYQRMTGRDIEKSICREMS GDLEEGMLAVVKCLKNTPAF FAERLNKAMRGAGTKDRTLI RIMVSRSETDLLDIRSEYKR MYGKSLYHDISGDTSGDYRK ILLKICGGND |
| Function | Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis. |
| Protein Name | Annexin A11 56 Kda Autoantigen Annexin Xi Annexin-11 Calcyclin-Associated Annexin 50 Cap-50 |
| Cellular Localisation | Cytoplasm Melanosome Nucleus Envelope Nucleus Nucleoplasm Cytoskeleton Spindle Found Throughout The Nucleoplasm At Interphase And During Mitosis Concentrates Around The Mitotic Apparatus Elevation Of Intracellular Calcium Causes Relocalization From The Nucleoplasm To The Nuclear Envelope With Little Effect On The Cytoplasmic Pool Localization To The Nuclear Envelope Is Cell-Cycle Dependent |
| Alternative Antibody Names | Anti-Annexin A11 antibody Anti-56 Kda Autoantigen antibody Anti-Annexin Xi antibody Anti-Annexin-11 antibody Anti-Calcyclin-Associated Annexin 50 antibody Anti-Cap-50 antibody Anti-ANXA11 antibody Anti-ANX11 antibody |
Information sourced from Uniprot.org