| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ANTXR1 (84-333) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANTXR1 |
| Gene ID: |
84168 |
| Uniprot ID: |
ANTR1_HUMAN |
| Immunogen Region: |
84-333 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 84-333 of human ANTXR1 (NP_060623.2). |
| Immunogen Sequence: |
VFSTRGTTLMKLTEDREQIR QGLEELQKVLPGGDTYMHEG FERASEQIYYENRQGYRTAS VIIALTDGELHEDLFFYSER EANRSRDLGAIVYCVGVKDF NETQLARIADSKDHVFPVND GFQALQGIIHSILKKSCIEI LAAEPSTICAGESFQVVVRG NGFRHARNVDRVLCSFKIND SVTLNEKPFSVEDTYLLCPA PILKEVGMKAALQVSMNDGL SFISSSVIITTTHCSLHKI |
| Tissue Specificity | Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells. |
| Function | Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. |
| Protein Name | Anthrax Toxin Receptor 1Tumor Endothelial Marker 8 |
| Database Links | Reactome: R-HSA-5210891 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionLamellipodium MembraneFilopodium MembraneAt The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched FilopodiaColocalizes With Actin At The Base Of Lamellipodia |
| Alternative Antibody Names | Anti-Anthrax Toxin Receptor 1 antibodyAnti-Tumor Endothelial Marker 8 antibodyAnti-ANTXR1 antibodyAnti-ATR antibodyAnti-TEM8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
