Anti-ANP32B antibody (1-100) [S2MR] (STJ11101882)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal PHAPI2/APRIL (1-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANP32B |
| Gene ID | 10541 |
| Uniprot ID | AN32B_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MDMKRRIHLELRNRTPAAVR ELVLDNCKSNDGKIEGLTAE FVNLEFLSLINVGLISVSNL PKLPKLKKLELSENRIFGGL DMLAEKLPNLTHLNLSGNKL |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ANP32B (Q92688). |
Additional Info
| Tissue Specificity | Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. |
| Post Translational Modifications | Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Directly cleaved by caspase-3/CASP3. |
| Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1. Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation. (Microbial infection) Plays an essential role in influenza A and B viral genome replication. Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm. |
| Protein Name | Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member BAcidic Protein Rich In LeucinesPutative Hla-Dr-Associated Protein I-2Phapi2Silver-Stainable Protein Ssp29 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusCytoplasmAccumulates In The Nuclei At The S PhaseIsoform 2: CytoplasmLacks A Nuclear Localization Signal |
| Alternative Antibody Names | Anti-Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B antibodyAnti-Acidic Protein Rich In Leucines antibodyAnti-Putative Hla-Dr-Associated Protein I-2 antibodyAnti-Phapi2 antibodyAnti-Silver-Stainable Protein Ssp29 antibodyAnti-ANP32B antibodyAnti-APRIL antibodyAnti-PHAPI2 antibody |
Information sourced from Uniprot.org