Anti-Ankyrin G antibody (Internal) (STJ73793)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Ankyrin G (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.IHC: Paraffin embedded Prostate and Human Brain (Cerebellum). Recommended concentration: 3.75µg/ml. Cryosection of immersion-fixed (1% PFA/0.5% methanol) Human Hypothalamus. Optimal dil |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ANK3 |
| Gene ID | 288 |
| Uniprot ID | ANK3_HUMAN |
| Accession Number | NP_066267.2; NP_001140.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | SWQNETSSGNLE |
Additional Info
| Function | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. |
| Protein Name | Ankyrin-3Ank-3Ankyrin-G |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-6807878 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonCell MembraneSarcolemmaPostsynaptic Cell MembraneLysosomeT-TubuleIn Skeletal MuscleLocalized At Costameres And Neuromuscular JunctionsIn MacrophagesAssociated With LysosomesIsoform 5: CytoplasmGolgi Apparatus |
| Alternative Antibody Names | Anti-Ankyrin-3 antibodyAnti-Ank-3 antibodyAnti-Ankyrin-G antibodyAnti-ANK3 antibody |
Information sourced from Uniprot.org