Anti-ANKH antibody (STJA0008741)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ANKH
General Information
| Short Description | Rabbit polyclonal anti-Mineralization regulator ANKH for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANKH |
| Gene ID | 56172 |
| Uniprot ID | ANKH_HUMAN |
| Immunogen | Synthesized peptide derived from human ANKH |
| Specificity | This antibody detects endogenous levels of ANKH at Human, Mouse, Rat |
Additional Info
| Function | Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated (Probable). |
| Protein Name | Mineralization Regulator AnkhAtp Carrier Protein AnkhProgressive Ankylosis Protein HomologAnk |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mineralization Regulator Ankh antibodyAnti-Atp Carrier Protein Ankh antibodyAnti-Progressive Ankylosis Protein Homolog antibodyAnti-Ank antibodyAnti-ANKH antibodyAnti-KIAA1581 antibodyAnti-UNQ241 antibodyAnti-PRO274 antibody |
Information sourced from Uniprot.org