| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ANKH (210-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANKH |
| Gene ID: |
56172 |
| Uniprot ID: |
ANKH_HUMAN |
| Immunogen Region: |
210-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 210-320 of human ANKH (NP_473368.1). |
| Immunogen Sequence: |
LGYYKNIHDIIPDRSGPELG GDATIRKMLSFWWPLALILA TQRISRPIVNLFVSRDLGGS SAATEAVAILTATYPVGHMP YGWLTEIRAVYPAFDKNNPS NKLVSTSNTVT |
| Tissue Specificity | Found in osteoblasts from mandibular bone and from iliac bone.not detected in osteoclastic cells. |
| Function | Transports adenosine triphosphate (ATP) and possibly other nucleoside triphosphates (NTPs) from cytosol to the extracellular space. Mainly regulates their levels locally in peripheral tissues while playing a minor systemic role. Prevents abnormal ectopic mineralization of the joints by regulating the extracellular levels of the calcification inhibitor inorganic pyrophosphate (PPi), which originates from the conversion of extracellular NTPs to NMPs and PPis by ENPP1. Regulates the release of the TCA cycle intermediates to the extracellular space, in particular citrate, succinate and malate. Extracellular citrate mostly present in bone tissue is required for osteogenic differentiation of mesenchymal stem cells, stabilization of hydroxyapatite structure and overall bone strength. The transport mechanism remains to be elucidated (Probable). |
| Protein Name | Mineralization Regulator AnkhAtp Carrier Protein AnkhProgressive Ankylosis Protein HomologAnk |
| Database Links | Reactome: R-HSA-5223345 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mineralization Regulator Ankh antibodyAnti-Atp Carrier Protein Ankh antibodyAnti-Progressive Ankylosis Protein Homolog antibodyAnti-Ank antibodyAnti-ANKH antibodyAnti-KIAA1581 antibodyAnti-UNQ241 antibodyAnti-PRO274 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
