Anti-ANKFY1 antibody (922-972 aa) (STJ197960)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human ANFY1 at the amino acid range 922-972
General Information
| Short Description | Rabbit polyclonal anti-Rabankyrin-5 (922-972 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ANKFY1 |
| Gene ID | 51479 |
| Uniprot ID | ANFY1_HUMAN |
| Immunogen | Synthesized peptide derived from the human ANFY1 at the amino acid range 922-972 |
| Immunogen Region | 922-972 aa |
| Specificity | This antibody detects endogenous levels of human ANFY1 |
Additional Info
| Function | Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis.the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. |
| Protein Name | Rabankyrin-5Rank-5Ankyrin Repeat And Fyve Domain-Containing Protein 1Ankyrin Repeats Hooked To A Zinc Finger Motif |
| Database Links | Reactome: R-HSA-9013405 |
| Cellular Localisation | CytoplasmEndosome MembranePeripheral Membrane ProteinEarly EndosomeAlso Associated With Endosomal MembranesLocalizes To Macropinosomes |
| Alternative Antibody Names | Anti-Rabankyrin-5 antibodyAnti-Rank-5 antibodyAnti-Ankyrin Repeat And Fyve Domain-Containing Protein 1 antibodyAnti-Ankyrin Repeats Hooked To A Zinc Finger Motif antibodyAnti-ANKFY1 antibodyAnti-ANKHZN antibodyAnti-KIAA1255 antibody |
Information sourced from Uniprot.org