Anti-ANK3 antibody (STJA0004415)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human ANK3
General Information
| Short Description | Rabbit polyclonal anti-Ankyrin-3 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.9 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:25-1:100 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ANK3 |
| Gene ID | 288 |
| Uniprot ID | ANK3_HUMAN |
| Immunogen | Synthetic peptide of human ANK3 |
Additional Info
| Tissue Specificity | Expressed in brain, neurons, muscles and other tissues. |
| Function | Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Required for intracellular adhesion and junctional conductance in myocytes, potentially via stabilization of GJA1/CX43 protein abundance and promotion of PKP2, GJA1/CX43, and SCN5A/Nav1.5 localization to cell-cell junctions. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. |
| Protein Name | Ankyrin-3Ank-3Ankyrin-G |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-6807878 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonCell MembraneSarcolemmaPostsynaptic Cell MembraneLysosomeT-TubuleIn Skeletal MuscleLocalized At Costameres And Neuromuscular JunctionsIn MacrophagesAssociated With LysosomesIsoform 5: CytoplasmGolgi Apparatus |
| Alternative Antibody Names | Anti-Ankyrin-3 antibodyAnti-Ank-3 antibodyAnti-Ankyrin-G antibodyAnti-ANK3 antibody |
Information sourced from Uniprot.org