| Host: |
Rabbit |
| Applications: |
IHC/ELISA |
| Reactivity: |
Human |
| Note: |
FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ankyrin-3 is suitable for use in Immunohistochemistry and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification: |
Affinity purification |
| Concentration: |
0.9 mg/mL |
| Dilution Range: |
IHC 1:25-1:100 |
| Storage Instruction: |
Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: |
ANK3 |
| Gene ID: |
288 |
| Uniprot ID: |
ANK3_HUMAN |
| Immunogen: |
Synthetic peptide of human ANK3 |
| Tissue Specificity | Expressed in brain, neurons, muscles and other tissues. |
| Function | In skeletal muscle, required for costamere localization of DMD and betaDAG1. Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. |
| Protein Name | Ankyrin-3Ank-3Ankyrin-G |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-6807878 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionAxonCell MembraneSarcolemmaPostsynaptic Cell MembraneLysosomeT-TubuleIn Skeletal MuscleLocalized At Costameres And Neuromuscular JunctionsIn MacrophagesAssociated With LysosomesIsoform 5: CytoplasmGolgi Apparatus |
| Alternative Antibody Names | Anti-Ankyrin-3 antibodyAnti-Ank-3 antibodyAnti-Ankyrin-G antibodyAnti-ANK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
