| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ANAPC7 (50-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ANAPC7Uniprot ID=APC7_HUMAN" |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ANAPC7 (NP_057322.2). |
| Immunogen Sequence: |
HSNVRLLSSLLLTMSNNNPE LFSPPQKYQLLVYHADSLFH DKEYRNAVSKYTMALQQKKA LSKTSKVRPSTGNSASTPQS QCLPSEIEVKYKMAECYTML K |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. APC7 is not required for the assembly of the APC/C complex, but has an enzyme-substrate adapter activity mediating the processive ubiquitination of specific substrates. Involved in brain development through the specific ubiquitination and clearance of MKI67 from constitutive heterochromatin after neuronal progenitors exit mitosis. |
| Protein Name | Anaphase-Promoting Complex Subunit 7Apc7Cyclosome Subunit 7 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusSpindleLocalizes To Spindle During Metaphase And To Cytoplasmic Microtubules During Interphase |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 7 antibodyAnti-Apc7 antibodyAnti-Cyclosome Subunit 7 antibodyAnti-ANAPC7 antibodyAnti-APC7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
