Anti-ANAPC11 antibody (Internal) (STJ72106)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ANAPC11 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 19kDa band observed in Human Brain (Cerebral and Frontal Cortex, Hippocampus) lysates (calculated MW of 20.6kDa according to NP_001002244.1). Recommended concentration: 0.3-1µg/ |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ANAPC11 |
| Gene ID | 51529 |
| Uniprot ID | APC11_HUMAN |
| Accession Number | NP_001002244.1; NP_057560.8 |
| Immunogen Region | Internal |
| Immunogen Sequence | PALDQETSSLLRCTS |
| Specificity | This antibody is expected to recognize. Reported variants represent identical protein: NP_057560.8, NP_001002248.1, NP_001002245.1, NP_001002246.1, NP_001002247.1, NP_001002249.1 |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. May recruit the E2 ubiquitin-conjugating enzymes to the complex. |
| Protein Name | Anaphase-Promoting Complex Subunit 11Apc11Cyclosome Subunit 11Hepatocellular Carcinoma-Associated Ring Finger Protein |
| Database Links | Reactome: R-HSA-141430Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-9687136Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Anaphase-Promoting Complex Subunit 11 antibodyAnti-Apc11 antibodyAnti-Cyclosome Subunit 11 antibodyAnti-Hepatocellular Carcinoma-Associated Ring Finger Protein antibodyAnti-ANAPC11 antibodyAnti-HSPC214 antibody |
Information sourced from Uniprot.org