Anti-AMSH antibody [R07-6D1] (STJA0035115)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human AMSH
General Information
| Short Description | Rabbit monoclonal anti-AMSH for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-6D1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | STAMBP |
| Gene ID | 10617 |
| Uniprot ID | STABP_HUMAN |
| Immunogen | A synthetic peptide of human AMSH |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated after BMP type I receptor activation. Ubiquitinated by SMURF2 in the presence of RNF11. |
| Function | Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF. Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7. Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization. Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways. |
| Protein Name | Stam-Binding ProteinAssociated Molecule With The Sh3 Domain Of StamEndosome-Associated Ubiquitin Isopeptidase |
| Database Links | Reactome: R-HSA-5689901 |
| Cellular Localisation | NucleusMembranePeripheral Membrane ProteinCytoplasmEarly Endosome |
| Alternative Antibody Names | Anti-Stam-Binding Protein antibodyAnti-Associated Molecule With The Sh3 Domain Of Stam antibodyAnti-Endosome-Associated Ubiquitin Isopeptidase antibodyAnti-STAMBP antibodyAnti-AMSH antibody |
Information sourced from Uniprot.org