| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AMOTL1 (810-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AMOTL1 |
| Gene ID: |
154810 |
| Uniprot ID: |
AMOL1_HUMAN |
| Immunogen Region: |
810-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 810-900 of human AMOTL1 (NP_570899.1). |
| Immunogen Sequence: |
LTSSQLAEEKKEEKTWKGSI GLLLGKEHHEHASAPLLPPP PTSALSSIASTTAASSAHAK TGSKDSSTQTDKSAELFWPS MASLPSRGRLS |
| Post Translational Modifications | Polyubiquitinated by NEDD4, leading to proteasomal degradation. |
| Function | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. |
| Protein Name | Angiomotin-Like Protein 1 |
| Database Links | Reactome: R-HSA-2028269 |
| Cellular Localisation | Cell JunctionTight Junction |
| Alternative Antibody Names | Anti-Angiomotin-Like Protein 1 antibodyAnti-AMOTL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
