| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AMH |
| Gene ID: |
268 |
| Uniprot ID: |
MIS_HUMAN |
| Immunogen Region: |
360-560 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-560 of human AMH (NP_000470.3). |
| Immunogen Sequence: |
PAPLHDPTSAPWATALARRV AAELQAAAAELRSLPGLPPA TAPLLARLLALCPGGPGGLG DPLRALLLLKALQGLRVEWR GRDPRGPGRAQRSAGATAAD GPCALRELSVDLRAERSVLI PETYQANNCQGVCGWPQSDR NPRYGNHVVLLLKMQVRGAA LARPPCCVPTAYAGKLLISL SEERISAHHVPNMVATECGC R |
| Tissue Specificity | In ovaries, AMH is detected in granulosa cells of early growing follicles. |
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting FactorAnti-Muellerian HormoneAmhMuellerian-Inhibiting SubstanceMis |
| Database Links | Reactome: R-HSA-201451Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Muellerian-Inhibiting Factor antibodyAnti-Anti-Muellerian Hormone antibodyAnti-Amh antibodyAnti-Muellerian-Inhibiting Substance antibodyAnti-Mis antibodyAnti-AMH antibodyAnti-MIF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
