| Post Translational Modifications | Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway. ISGylated. |
| Function | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. |
| Protein Name | Glucose-6-Phosphate IsomeraseGpiAutocrine Motility FactorAmfNeuroleukinNlkPhosphoglucose IsomerasePgiPhosphohexose IsomerasePhiSperm Antigen 36Sa-36 |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-6798695Reactome: R-HSA-70171Reactome: R-HSA-70263 |
| Cellular Localisation | CytoplasmSecreted |
| Alternative Antibody Names | Anti-Glucose-6-Phosphate Isomerase antibodyAnti-Gpi antibodyAnti-Autocrine Motility Factor antibodyAnti-Amf antibodyAnti-Neuroleukin antibodyAnti-Nlk antibodyAnti-Phosphoglucose Isomerase antibodyAnti-Pgi antibodyAnti-Phosphohexose Isomerase antibodyAnti-Phi antibodyAnti-Sperm Antigen 36 antibodyAnti-Sa-36 antibodyAnti-GPI antibody |
Information sourced from Uniprot.org
