Anti-AMER1 antibody (STJA0008488)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human WTX
General Information
| Short Description | Rabbit polyclonal anti-APC membrane recruitment protein 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AMER1 |
| Gene ID | 139285 |
| Uniprot ID | AMER1_HUMAN |
| Immunogen | Synthesized peptide derived from human WTX |
| Specificity | This antibody detects endogenous levels of WTX at Human, Mouse |
Additional Info
| Function | Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development. |
| Protein Name | Apc Membrane Recruitment Protein 1Amer1Protein Fam123bWilms Tumor Gene On The X Chromosome Protein |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusShuttles Between Nucleus And CytoplasmDetected In Nuclear Paraspeckles That Are Found Close To Splicing SpecklesTranslocates To The Cell Membrane Following Binding To Ptdins(45)P2 |
| Alternative Antibody Names | Anti-Apc Membrane Recruitment Protein 1 antibodyAnti-Amer1 antibodyAnti-Protein Fam123b antibodyAnti-Wilms Tumor Gene On The X Chromosome Protein antibodyAnti-AMER1 antibodyAnti-FAM123B antibodyAnti-WTX antibody |
Information sourced from Uniprot.org