Anti-alpha COP I antibody [R05-6F3] (STJA0037133)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human COPA
General Information
| Short Description | Rabbit monoclonal anti-alpha COP I for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-6F3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | COPA |
| Gene ID | 1314 |
| Uniprot ID | COPA_HUMAN |
| Immunogen | A synthesized peptide derived from human COPA |
Additional Info
| Tissue Specificity | Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells. |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins.the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| Protein Name | Coatomer Subunit AlphaAlpha-Coat ProteinAlpha-CopHep-CopHepcop Cleaved Into - XeninXenopsin-Related Peptide - Proxenin |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleCopi-Coated Vesicle MembraneThe Coatomer Is Cytoplasmic Or Polymerized On The Cytoplasmic Side Of The GolgiAs Well As On The Vesicles/Buds Originating From ItXenin: Secreted |
| Alternative Antibody Names | Anti-Coatomer Subunit Alpha antibodyAnti-Alpha-Coat Protein antibodyAnti-Alpha-Cop antibodyAnti-Hep-Cop antibodyAnti-Hepcop Cleaved Into - Xenin antibodyAnti-Xenopsin-Related Peptide - Proxenin antibodyAnti-COPA antibody |
Information sourced from Uniprot.org