Anti-ALKBH8 antibody (27-77) (STJA0006515)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ALKB8 AA range: 27-77
General Information
| Short Description | Rabbit polyclonal anti-Alkylated DNA repair protein alkB homolog 8-5-O-methyltransferase ABH8 (27-77) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALKBH8 |
| Gene ID | 91801 |
| Uniprot ID | ALKB8_HUMAN |
| Immunogen | Synthesized peptide derived from human ALKB8 AA range: 27-77 |
| Immunogen Region | 27-77 |
| Specificity | This antibody detects endogenous levels of human ALKB8 |
Additional Info
| Function | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine.has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. |
| Protein Name | TrnaCarboxymethyluridine(34-5-O-Methyltransferase Alkbh8Alkylated Dna Repair Protein Alkb Homolog 8Alpha-Ketoglutarate-Dependent Dioxygenase Alkbh8S-Adenosyl-L-Methionine-Dependent Trna Methyltransferase Alkbh8 |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmNucleusPredominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Carboxymethyluridine(34-5-O-Methyltransferase Alkbh8 antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 8 antibodyAnti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkbh8 antibodyAnti-S-Adenosyl-L-Methionine-Dependent Trna Methyltransferase Alkbh8 antibodyAnti-ALKBH8 antibodyAnti-ABH8 antibody |
Information sourced from Uniprot.org