Anti-ALKBH4 antibody (STJ191915)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALKBH4 |
| Gene ID | 54784 |
| Uniprot ID | ALKB4_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | ALKB4 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4Alkylated Dna Repair Protein Alkb Homolog 4Dna N6-Methyl Adenine Demethylase Alkbh4Lysine-Specific Demethylase Alkbh4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusMidbodyAssociates With The Contractile Ring And Midbody |
| Alternative Antibody Names | Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 4 antibodyAnti-Dna N6-Methyl Adenine Demethylase Alkbh4 antibodyAnti-Lysine-Specific Demethylase Alkbh4 antibodyAnti-ALKBH4 antibodyAnti-ABH4 antibody |
Information sourced from Uniprot.org