Anti-ALK-1 antibody [R07-5K6] (STJA0036464)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human ACVRL1
General Information
| Short Description | Rabbit monoclonal anti-ALK-1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-5K6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ACVRL1 |
| Gene ID | 94 |
| Uniprot ID | ACVL1_HUMAN |
| Immunogen | A synthesized peptide derived from human ACVRL1 |
Additional Info
| Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
| Protein Name | Activin Receptor Type-1-LikeActivin Receptor-Like Kinase 1Alk-1Serine/Threonine-Protein Kinase Receptor R3Skr3Tgf-B Superfamily Receptor Type ITsr-I |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-1-Like antibodyAnti-Activin Receptor-Like Kinase 1 antibodyAnti-Alk-1 antibodyAnti-Serine/Threonine-Protein Kinase Receptor R3 antibodyAnti-Skr3 antibodyAnti-Tgf-B Superfamily Receptor Type I antibodyAnti-Tsr-I antibodyAnti-ACVRL1 antibodyAnti-ACVRLK1 antibodyAnti-ALK1 antibody |
Information sourced from Uniprot.org