Anti-ALG11 antibody (STJA0004441)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human ALG11
General Information
| Short Description | Rabbit polyclonal anti-Gdp-Man-Man (3glcnac (2-Pp-Dol Alpha-1-2-Mannosyltransferase for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:100-1:300 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | ALG11 |
| Gene ID | 440138 |
| Uniprot ID | ALG11_HUMAN |
| Immunogen | Synthetic peptide of human ALG11 |
Additional Info
| Function | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway. |
| Protein Name | Gdp-Man -Man(3glcnac(2-Pp-Dol Alpha-1 -2-MannosyltransferaseAsparagine-Linked Glycosylation Protein 11 HomologGlycolipid 2-Alpha-Mannosyltransferase |
| Database Links | Reactome: R-HSA-446193Reactome: R-HSA-4551295 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gdp-Man -Man(3glcnac(2-Pp-Dol Alpha-1 -2-Mannosyltransferase antibodyAnti-Asparagine-Linked Glycosylation Protein 11 Homolog antibodyAnti-Glycolipid 2-Alpha-Mannosyltransferase antibodyAnti-ALG11 antibodyAnti-GT8 antibody |
Information sourced from Uniprot.org