Anti-ALDH2 antibody [8D4-D6-D11] (STJA0032435)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant human ALDH2 protein fragments expressed in E.coli
General Information
| Short Description | Mouse monoclonal anti-ALDH2 for use in WB in Human, Mouse, Rat, Monkey and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat/Monkey/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 8D4-D6-D11 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 4.5 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ALDH2 |
| Gene ID | 217 |
| Uniprot ID | ALDH2_HUMAN |
| Immunogen | Purified recombinant human ALDH2 protein fragments expressed in E.coli |
Additional Info
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. |
| Protein Name | Aldehyde Dehydrogenase - MitochondrialAldh Class 2Aldh-E2Aldhi |
| Database Links | Reactome: R-HSA-380612Reactome: R-HSA-445355Reactome: R-HSA-71384Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Aldehyde Dehydrogenase - Mitochondrial antibodyAnti-Aldh Class 2 antibodyAnti-Aldh-E2 antibodyAnti-Aldhi antibodyAnti-ALDH2 antibodyAnti-ALDM antibody |
Information sourced from Uniprot.org