| Short Description : | Rabbit monoclonal ALDH2 (100-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S8MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ALDH2 |
| Gene ID: | 217 |
| Uniprot ID: | ALDH2_HUMAN |
| Immunogen Region: | 100-200 |
| Immunogen Sequence: | HRGRLLNRLADLIERDRTYL AALETLDNGKPYVISYLVDL DMVLKCLRYYAGWADKYHGK TIPIDGDFFSYTRHEPVGVC GQIIPWNFPLLMQAWKLGPA L |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ALDH2 (P05091). |
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. |
| Protein Name | Aldehyde Dehydrogenase - MitochondrialAldh Class 2Aldh-E2Aldhi |
| Database Links | Reactome: R-HSA-380612Reactome: R-HSA-445355Reactome: R-HSA-71384Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Aldehyde Dehydrogenase - Mitochondrial antibodyAnti-Aldh Class 2 antibodyAnti-Aldh-E2 antibodyAnti-Aldhi antibodyAnti-ALDH2 antibodyAnti-ALDM antibody |
Information sourced from Uniprot.org
