Anti-ALDH18A1 antibody (1-240) (STJ114138)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ALDH18A1 (1-240) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALDH18A1 |
| Gene ID | 5832 |
| Uniprot ID | P5CS_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MLSQVYRCGFQPFNQHLLPW VKCTTVFRSHCIQPSVIRHV RSWSNIPFITVPLSRTHGKS FAHRSELKHAKRIVVKLGSA VVTRGDECGLALGRLASIVE QVSVLQNQGREMMLVTSGAV AFGKQRLRHEILLSQSVRQA LHSGQNQLKEMAIPVLEARA CAAAGQSGLMALYEAMFTQY SICAAQILVTNLDFHDEQKR RNLNGTLHELLRMNIVPIVN TNDAVVPPAEPNSDLQGVN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851.2). |
Additional Info
| Function | Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. |
| Protein Name | Delta-1-Pyrroline-5-Carboxylate SynthaseP5csAldehyde Dehydrogenase Family 18 Member A1 Includes - Glutamate 5-KinaseGkGamma-Glutamyl Kinase - Gamma-Glutamyl Phosphate ReductaseGprGlutamate-5-Semialdehyde DehydrogenaseGlutamyl-Gamma-Semialdehyde Dehydrogenase |
| Database Links | Reactome: R-HSA-8964539Reactome: R-HSA-9837999 |
| Cellular Localisation | MitochondrionMitochondrion MatrixExhibits Puncta-Like Structures Inside Mitochondria Under Nutrient StressWhen Cellular Dependence On Oxidative Phosphorylation IncreasesForms FilamentsWhich May Increase Its ActivityAnd Is Sequestered In A Subset Of Atypical Mitochondria That Lack Cristae And Atp Synthase |
| Alternative Antibody Names | Anti-Delta-1-Pyrroline-5-Carboxylate Synthase antibodyAnti-P5cs antibodyAnti-Aldehyde Dehydrogenase Family 18 Member A1 Includes - Glutamate 5-Kinase antibodyAnti-Gk antibodyAnti-Gamma-Glutamyl Kinase - Gamma-Glutamyl Phosphate Reductase antibodyAnti-Gpr antibodyAnti-Glutamate-5-Semialdehyde Dehydrogenase antibodyAnti-Glutamyl-Gamma-Semialdehyde Dehydrogenase antibodyAnti-ALDH18A1 antibodyAnti-GSAS antibodyAnti-P5CS antibodyAnti-PYCS antibody |
Information sourced from Uniprot.org