Anti-Aldehyde dehydrogenase 2/ALDH2 antibody (18-517aa) [AT2C10] (STJA0041824)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenRecombinant human ALDH2 (18-517aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Aldehyde dehydrogenase 2/ALDH2 (18-517aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT2C10 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALDH2 |
| Gene ID | 217 |
| Uniprot ID | ALDH2_HUMAN |
| Accession Number | NP_000681 |
| Immunogen | Recombinant human ALDH2 (18-517aa) purified from E. coli |
| Immunogen Region | 18-517aa |
Additional Info
| Post Translational Modifications | In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. |
| Function | Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. |
| Protein Name | Aldehyde Dehydrogenase - MitochondrialAldh Class 2Aldh-E2Aldhi |
| Database Links | Reactome: R-HSA-380612Reactome: R-HSA-445355Reactome: R-HSA-71384Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Aldehyde Dehydrogenase - Mitochondrial antibodyAnti-Aldh Class 2 antibodyAnti-Aldh-E2 antibodyAnti-Aldhi antibodyAnti-ALDH2 antibodyAnti-ALDM antibody |
Information sourced from Uniprot.org