| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ALAS1 (1-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ALAS1 |
| Gene ID: |
211 |
| Uniprot ID: |
HEM1_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALAS1 (NP_954635.1). |
| Immunogen Sequence: |
MESVVRRCPFLSRVPQAFLQ KAGKSLLFYAQNCPKMMEVG AKPAPRALSTAAVHYQQIKE TPPASEKDKTAKAKVQQTPD GSQQSPDGTQLPSGHPLPAT SQGTASKCPFLAAQMNQRGS SVFCKASLELQEDVQEMNAV RKEVAETSAGPSVVSVKTDG GDPSGLLKNFQDIMQKQRPE RVSHLLQDNLPKSVSTFQYD RFFEKKIDEKKNDHTYRVFK TVNRRAHIFPMADDYSDSL |
| Post Translational Modifications | In normoxia, is hydroxylated at Pro-576, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome. Ubiquitinated.in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome. |
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. |
| Protein Name | 5-Aminolevulinate Synthase - Non-Specific - MitochondrialAlas-H5-Aminolevulinic Acid Synthase 1Delta-Ala Synthase 1Delta-Aminolevulinate Synthase 1 |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-1989781Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-5-Aminolevulinate Synthase - Non-Specific - Mitochondrial antibodyAnti-Alas-H antibodyAnti-5-Aminolevulinic Acid Synthase 1 antibodyAnti-Delta-Ala Synthase 1 antibodyAnti-Delta-Aminolevulinate Synthase 1 antibodyAnti-ALAS1 antibodyAnti-ALAS3 antibodyAnti-ALASH antibodyAnti-OK antibodyAnti-SW-cl.121 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
