Anti-AKR1B1 antibody (241-290 aa) (STJ91559)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human AKR1B1 at the amino acid range 241-290
General Information
| Short Description | Rabbit polyclonal anti-Aldo-keto reductase family 1 member B1 (241-290 aa) for use in WB, IHC, IF and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AKR1B1 |
| Gene ID | 231 |
| Uniprot ID | ALDR_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human AKR1B1 at the amino acid range 241-290 |
| Immunogen Region | 241-290 aa |
| Specificity | Aldose Reductase Polyclonal Antibody detects endogenous levels of Aldose Reductase protein. |
Additional Info
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). |
| Protein Name | Aldo-Keto Reductase Family 1 Member B1 Aldehyde ReductaseAldose ReductaseAr |
| Database Links | Reactome: R-HSA-196108Reactome: R-HSA-5652227 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member B1 antibodyAnti-Aldehyde Reductase antibodyAnti-Aldose Reductase antibodyAnti-Ar antibodyAnti-AKR1B1 antibodyAnti-ALDR1 antibodyAnti-ALR2 antibody |
Information sourced from Uniprot.org