Anti-AK6 antibody (11-60 aa) (STJ91523)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human KAD6 at the amino acid range 11-60
General Information
| Short Description | Rabbit polyclonal anti-Adenylate kinase isoenzyme 6 (11-60 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AK6 |
| Gene ID | 102157402 |
| Uniprot ID | KAD6_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human KAD6 at the amino acid range 11-60 |
| Immunogen Region | 11-60 aa |
| Specificity | AK6 Polyclonal Antibody detects endogenous levels of AK6 protein. |
Additional Info
| Function | Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May be involved in regulation of Cajal body (CB) formation. |
| Protein Name | Adenylate Kinase Isoenzyme 6Ak6Adrenal Gland Protein Ad-004Coilin-Interacting Nuclear Atpase ProteinHcinapDual Activity Adenylate Kinase/AtpaseAk/Atpase |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmCajal BodyDisplays Widespread Diffuse Nucleoplasmic Distribution But Not Detected In NucleoliDetected In Cajal Bodies But Not In All Cells |
| Alternative Antibody Names | Anti-Adenylate Kinase Isoenzyme 6 antibodyAnti-Ak6 antibodyAnti-Adrenal Gland Protein Ad-004 antibodyAnti-Coilin-Interacting Nuclear Atpase Protein antibodyAnti-Hcinap antibodyAnti-Dual Activity Adenylate Kinase/Atpase antibodyAnti-Ak/Atpase antibodyAnti-AK6 antibodyAnti-CINAP antibodyAnti-AD-004 antibodyAnti-CGI-137 antibody |
Information sourced from Uniprot.org