Anti-AK4 antibody (STJA0008417)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human AK3L1
General Information
| Short Description | Rabbit polyclonal anti-Adenylate kinase 4, mitochondrial for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AK4 |
| Gene ID | 205 |
| Uniprot ID | KAD4_HUMAN |
| Immunogen | Synthesized peptide derived from human AK3L1 |
| Specificity | This antibody detects endogenous levels of AK3L1 at Human, Mouse, Rat |
Additional Info
| Function | Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress. |
| Protein Name | Adenylate Kinase 4 - MitochondrialAdenylate Kinase 3-LikeGtp -Amp Phosphotransferase Ak4 |
| Database Links | Reactome: R-HSA-499943 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Adenylate Kinase 4 - Mitochondrial antibodyAnti-Adenylate Kinase 3-Like antibodyAnti-Gtp -Amp Phosphotransferase Ak4 antibodyAnti-AK4 antibodyAnti-AK3 antibodyAnti-AK3L1 antibody |
Information sourced from Uniprot.org