Anti-AIF1/IBA1 antibody [SMM14980] (STJ11109710)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Mouse monoclonal AIF1/IBA1 antibody for use in WB, IF-F, IF-P, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF-F/IF-P/IHC-P/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SMM14980 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:1000-1:3000IF-F, 1:100-1:400IF-P, 1:100-1:400IHC-P, 1:10000-1:50000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Aif1 |
| Gene ID | 11629 |
| Uniprot ID | AIF1_MOUSE |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Protein Name | Allograft Inflammatory Factor 1Aif-1Ionized Calcium-Binding Adapter Molecule 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePhagocytic CupAssociated With The Actin Cytoskeleton At Membrane Ruffles And At Sites Of Phagocytosis |
| Alternative Antibody Names | Anti-Allograft Inflammatory Factor 1 antibodyAnti-Aif-1 antibodyAnti-Ionized Calcium-Binding Adapter Molecule 1 antibodyAnti-Aif1 antibodyAnti-Iba1 antibody |
Information sourced from Uniprot.org