Anti-AIBZIP/CREB3L4, Biotinylated antibody (C-Term) {Biotin} (STJ73281)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationBiotin
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-AIBZIP/CREB3L4, Biotinylated (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 50kDa band observed in Human Placenta lysates (calculated MW of 43.4kDa according to NP_570968.1). See non-biotinylated parental product's datasheet for further QC data. Recomme |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CREB3L4 |
| Gene ID | 148327 |
| Uniprot ID | CR3L4_HUMAN |
| Accession Number | NP_570968.1; NP_001242909.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | CPSGRIRSVLHADEM. |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_570968.1; NP_001242909.1). Reported variants represent identical protein: NP_001242908.1, NP_570968.1, NP_001242907.1 Reported variants represent identical protein: NP_001242909.1, NP_ |
Additional Info
| Post Translational Modifications | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-TGTACGTGAGT-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4Camp-Responsive Element-Binding Protein 3-Like Protein 4Androgen-Induced Basic Leucine Zipper ProteinAibzipAttaching To Cre-Like 1Atce1Cyclic Amp-Responsive Element-Binding Protein 4Creb-4Camp-Responsive Element-Binding Protein 4Transcript Induced In Spermiogenesis Protein 40Tisp40Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneMay Also Be Located In Golgi ApparatusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Androgen-Induced Basic Leucine Zipper Protein antibodyAnti-Aibzip antibodyAnti-Attaching To Cre-Like 1 antibodyAnti-Atce1 antibodyAnti-Cyclic Amp-Responsive Element-Binding Protein 4 antibodyAnti-Creb-4 antibodyAnti-Camp-Responsive Element-Binding Protein 4 antibodyAnti-Transcript Induced In Spermiogenesis Protein 40 antibodyAnti-Tisp40 antibodyAnti-Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-CREB3L4 antibodyAnti-AIBZIP antibodyAnti-CREB4 antibodyAnti-JAL antibody |
Information sourced from Uniprot.org