Anti-AHSA1 antibody (239-338) [S5MR] (STJ11102485)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal AHA1 (239-338) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AHSA1 |
| Gene ID | 10598 |
| Uniprot ID | AHSA1_HUMAN |
| Immunogen Region | 239-338 |
| Immunogen Sequence | PATLEADRGGKFHMVDGNVS GEFTDLVPEKHIVMKWRFKS WPEGHFATITLTFIDKNGET ELCMEGRGIPAPEEERTRQG WQRYYFEGIKQTFGYGARLF |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 239-338 of human AHA1 (O95433). |
Additional Info
| Tissue Specificity | Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta. |
| Post Translational Modifications | Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1. |
| Function | Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. |
| Protein Name | Activator Of 90 Kda Heat Shock Protein Atpase Homolog 1Aha1P38 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumMay Transiently Interact With The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Activator Of 90 Kda Heat Shock Protein Atpase Homolog 1 antibodyAnti-Aha1 antibodyAnti-P38 antibodyAnti-AHSA1 antibodyAnti-C14orf3 antibodyAnti-HSPC322 antibody |
Information sourced from Uniprot.org