Anti-AHA1 antibody [R01-8D9] (STJA0033992)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human AHA1
General Information
| Short Description | Rabbit monoclonal anti-AHA1 for use in WB and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-8D9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | AHSA1 |
| Gene ID | 10598 |
| Uniprot ID | AHSA1_HUMAN |
| Immunogen | A synthetic peptide of human AHA1 |
Additional Info
| Tissue Specificity | Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta. |
| Post Translational Modifications | Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1. |
| Function | Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. |
| Protein Name | Activator Of 90 Kda Heat Shock Protein Atpase Homolog 1Aha1P38 |
| Database Links | |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumMay Transiently Interact With The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Activator Of 90 Kda Heat Shock Protein Atpase Homolog 1 antibodyAnti-Aha1 antibodyAnti-P38 antibodyAnti-AHSA1 antibodyAnti-C14orf3 antibodyAnti-HSPC322 antibody |
Information sourced from Uniprot.org