Anti-AGTRAP antibody (93-152) (STJ114071)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal AGTRAP (93-152) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AGTRAP |
| Gene ID | 57085 |
| Uniprot ID | ATRAP_HUMAN |
| Immunogen Region | 93-152 |
| Immunogen Sequence | ILSLLLKPLSCCFVYHMYRE RGGELLVHTGFLGSSQDRSA YQTIDSAEAPADPFAVPEGR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 93-152 of human AGTRAP (NP_065083.3). |
Additional Info
| Tissue Specificity | Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. |
| Function | Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. |
| Protein Name | Type-1 Angiotensin Ii Receptor-Associated ProteinAt1 Receptor-Associated Protein |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCytoplasmic Vesicle MembranePresent In Perinuclear Vesicular MembranesEndoplasmic ReticulumGolgi And Endocytic Vesicles |
| Alternative Antibody Names | Anti-Type-1 Angiotensin Ii Receptor-Associated Protein antibodyAnti-At1 Receptor-Associated Protein antibodyAnti-AGTRAP antibodyAnti-ATRAP antibody |
Information sourced from Uniprot.org