Anti-AGTR2 antibody (150-250) (STJ11104644)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Type-2 Angiotensin Ii Receptor (150-250) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AGTR2 |
| Gene ID | 186 |
| Uniprot ID | AGTR2_HUMAN |
| Immunogen Region | 150-250 |
| Immunogen Sequence | FLSQRRNPWQASYIVPLVWC MACLSSLPTFYFRDVRTIEY LGVNACIMAFPPEKYAQWSA GIALMKNILGFIIPLIFIAT CYFGIRKHLLKTNSYGKNRI T |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human AGTR2 (NP_000677.2). |
Additional Info
| Tissue Specificity | In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. |
| Function | Receptor for angiotensin II, a vasoconstricting peptide. Signals primarily via a non-canonical G-protein- and beta-arrestin independent pathways. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. |
| Protein Name | Type-2 Angiotensin Ii ReceptorAngiotensin Ii Type-2 ReceptorAt2 Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Type-2 Angiotensin Ii Receptor antibodyAnti-Angiotensin Ii Type-2 Receptor antibodyAnti-At2 Receptor antibodyAnti-AGTR2 antibody |
Information sourced from Uniprot.org