![Anti-AGTR1 nanobody [SAA1316] (STJN000194)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200807/412989/STJN000194-SDS-PAGE-1__72436.1749232512.jpg?c=1 "Anti-AGTR1 nanobody [SAA1316] (STJN000194)")
![Anti-AGTR1 nanobody [SAA1316] (STJN000194)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200807/412989/STJN000194-SDS-PAGE-1__72436.1749232512.jpg?c=1 "Anti-AGTR1 nanobody [SAA1316] (STJN000194)")
Anti-AGTR1 nanobody [SAA1316] (STJN000194)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Type-1 Angiotensin Ii Receptor is suitable for use in Flow Cytometry, Immunoprecipitation and RIA research applications. |
| Applications | FC/IP/RIA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1316 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 0.18 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | AGTR1 |
| Gene ID | 185 |
| Uniprot ID | AGTR1_HUMAN |
Additional Info
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. |
| Protein Name | Type-1 Angiotensin Ii ReceptorAt1arAt1brAngiotensin Ii Type-1 ReceptorAt1 Receptor |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Type-1 Angiotensin Ii Receptor nanobodyAnti-At1ar nanobodyAnti-At1br nanobodyAnti-Angiotensin Ii Type-1 Receptor nanobodyAnti-At1 Receptor nanobodyAnti-AGTR1 nanobodyAnti-AGTR1A nanobodyAnti-AGTR1B nanobodyAnti-AT2R1 nanobodyAnti-AT2R1B nanobody |
Information sourced from Uniprot.org