Anti-AGRP antibody (21-70) (STJA0010162)

SKU:
STJA0010162

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Agouti-related protein (21-70) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AGRP
Gene ID: 181
Uniprot ID: AGRP_HUMAN
Immunogen Region: 21-70
Specificity: This antibody detects endogenous levels of Human AGRP
Immunogen: Synthesized peptide derived from human AGRP AA range: 21-70
Tissue Specificity Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Function Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Protein Name Agouti-Related Protein
Database Links Reactome: R-HSA-9615017
Cellular Localisation Secreted
Golgi Apparatus Lumen
Alternative Antibody Names Anti-Agouti-Related Protein antibody
Anti-AGRP antibody
Anti-AGRT antibody
Anti-ART antibody

Information sourced from Uniprot.org

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