Anti-AGO1 antibody (STJA0007760)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human EIF2C1
General Information
| Short Description | Rabbit polyclonal anti-Protein argonaute-1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AGO1 |
| Gene ID | 26523 |
| Uniprot ID | AGO1_HUMAN |
| Immunogen | Synthesized peptide derived from human EIF2C1 |
| Specificity | This antibody detects endogenous levels of EIF2C1 at Human, Mouse |
Additional Info
| Function | Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs). |
| Protein Name | Protein Argonaute-1Argonaute1Hago1Argonaute Risc Catalytic Component 1Eukaryotic Translation Initiation Factor 2c 1Eif-2c 1Eif2c 1Putative Rna-Binding Protein Q99 |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-203927Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-4086398Reactome: R-HSA-426486Reactome: R-HSA-426496Reactome: R-HSA-5578749Reactome: R-HSA-5628897Reactome: R-HSA-5687128Reactome: R-HSA-8853884Reactome: R-HSA-8934593Reactome: R-HSA-8936459Reactome: R-HSA-8943723Reactome: R-HSA-8948700Reactome: R-HSA-8986944Reactome: R-HSA-9018519Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9725371Reactome: R-HSA-9759811Reactome: R-HSA-9768778Reactome: R-HSA-9824594Reactome: R-HSA-9839394 |
| Cellular Localisation | CytoplasmP-Body |
| Alternative Antibody Names | Anti-Protein Argonaute-1 antibodyAnti-Argonaute1 antibodyAnti-Hago1 antibodyAnti-Argonaute Risc Catalytic Component 1 antibodyAnti-Eukaryotic Translation Initiation Factor 2c 1 antibodyAnti-Eif-2c 1 antibodyAnti-Eif2c 1 antibodyAnti-Putative Rna-Binding Protein Q99 antibodyAnti-AGO1 antibodyAnti-EIF2C1 antibody |
Information sourced from Uniprot.org