| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AGMAT |
| Gene ID: | 79814 |
| Uniprot ID: | GDAH_HUMAN |
| Immunogen Region: | 1-352 |
| Immunogen Sequence: | MLRLLASGCARGPGPGVGAR PAAGLFHPGRRQSRQASDAP RNQPPSPEFVARPVGVCSMM RLPVQTSPEGLDAAFIGVPL DTGTSNRPGARFGPRRIREE SVMLGTVNPSTGALPFQSLM VADLGDVNVNLYNLQDSCRR IQEAYEKIVAAGCIPLTLGG DHTITYPILQAMAKKHGPVG LLHVDAHTDTTDKALGEKLY HGAPFRRCVDEGLLDCKRVV QIGIRGSSTTLDPYRYNRS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human AGMAT (NP_079034.3). |
| Tissue Specificity | Highly expressed in liver and kidney. Also found in skeletal muscle, fetal liver, brain, testis, skin and the gastrointestinal tract. Within brain, expression is higher in the cerebral cortex with lower levels in the medulla and spinal cord. |
| Function | Hydrolyzes linear guanidino acids to form urea and the corresponding amines. Displays specificity for substrates having a negatively charged head group and short chains including taurocyamine, guanidino propanoic and butanoic acids. May protect cells by detoxifying potentially harmful amounts of guanidino acids. Metabolizes L-arginine with low efficiency. |
| Protein Name | Guanidino Acid Hydrolase - MitochondrialArginase - MitochondrialGuanidinobutyrase - MitochondrialGuanidinopropionase - Mitochondrial |
| Database Links | Reactome: R-HSA-351143 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Guanidino Acid Hydrolase - Mitochondrial antibodyAnti-Arginase - Mitochondrial antibodyAnti-Guanidinobutyrase - Mitochondrial antibodyAnti-Guanidinopropionase - Mitochondrial antibodyAnti-AGMAT antibodyAnti-GDAH antibody |
Information sourced from Uniprot.org
