Anti-Aggrecan antibody (200-250 aa) (STJ13100037)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 200-250 of human Aggrecan conjugated to blue carrier protein was used as the antigen. The peptide is homologous with rat and mouse sequences.
General Information
| Short Description | Rabbit polyclonal anti-Aggrecan (200-250 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ACAN |
| Gene ID | 176 |
| Uniprot ID | PGCA_HUMAN |
| Immunogen | A synthetic peptide from aa region 200-250 of human Aggrecan conjugated to blue carrier protein was used as the antigen. The peptide is homologous with rat and mouse sequences. |
| Immunogen Region | 200-250 aa |
| Specificity | Specific for Aggrecan. |
Additional Info
| Post Translational Modifications | Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. |
| Function | This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. |
| Protein Name | Aggrecan Core ProteinCartilage-Specific Proteoglycan Core ProteinCspcpChondroitin Sulfate Proteoglycan Core Protein 1Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022854Reactome: R-HSA-2022857Reactome: R-HSA-3000178Reactome: R-HSA-3656225Reactome: R-HSA-3656243Reactome: R-HSA-3656244 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Aggrecan Core Protein antibodyAnti-Cartilage-Specific Proteoglycan Core Protein antibodyAnti-Cspcp antibodyAnti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibodyAnti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibodyAnti-ACAN antibodyAnti-AGC1 antibodyAnti-CSPG1 antibodyAnti-MSK16 antibody |
Information sourced from Uniprot.org