Anti-AGAP2 antibody (STJA0009599)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human AGAP2
General Information
| Short Description | Rabbit polyclonal anti-Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AGAP2 |
| Gene ID | 116986 |
| Uniprot ID | AGAP2_HUMAN |
| Immunogen | Synthesized peptide derived from human AGAP2 |
| Specificity | This antibody detects endogenous levels of AGAP2 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage. |
| Function | GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. |
| Protein Name | Arf-Gap With Gtpase - Ank Repeat And Ph Domain-Containing Protein 2Agap-2Centaurin-Gamma-1Cnt-G1Gtp-Binding And Gtpase-Activating Protein 2Ggap2Phosphatidylinositol 3-Kinase EnhancerPike |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Isoform 1: CytoplasmNucleusIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Arf-Gap With Gtpase - Ank Repeat And Ph Domain-Containing Protein 2 antibodyAnti-Agap-2 antibodyAnti-Centaurin-Gamma-1 antibodyAnti-Cnt-G1 antibodyAnti-Gtp-Binding And Gtpase-Activating Protein 2 antibodyAnti-Ggap2 antibodyAnti-Phosphatidylinositol 3-Kinase Enhancer antibodyAnti-Pike antibodyAnti-AGAP2 antibodyAnti-CENTG1 antibodyAnti-KIAA0167 antibody |
Information sourced from Uniprot.org