Anti-AFG2B antibody (STJA0009038)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SPATA5L1
General Information
| Short Description | Rabbit polyclonal anti-ATPase family gene 2 protein homolog B for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AFG2B |
| Gene ID | 79029 |
| Uniprot ID | AFG2B_HUMAN |
| Immunogen | Synthesized peptide derived from human SPATA5L1 |
| Specificity | This antibody detects endogenous levels of SPATA5L1 at Human |
Additional Info
| Function | ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. |
| Protein Name | Atpase Family Gene 2 Protein Homolog BAfg2 Aaa Atpase Homolog BRibosome Biogenesis Protein Spata5l1Spermatogenesis-Associated Protein 5-Like Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSpindleNucleus |
| Alternative Antibody Names | Anti-Atpase Family Gene 2 Protein Homolog B antibodyAnti-Afg2 Aaa Atpase Homolog B antibodyAnti-Ribosome Biogenesis Protein Spata5l1 antibodyAnti-Spermatogenesis-Associated Protein 5-Like Protein 1 antibodyAnti-AFG2B antibodyAnti-SPATA5L1 antibody |
Information sourced from Uniprot.org