Anti-AES antibody (N-Term) (STJ72590)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-AES (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 30kDa band observed in Human Brain (Cerebellum and Cerebral Cortex) lysates (calculated MW of 29.1kDa according to NP_945320.1). Recommended concentration: 0.3-1Β΅g/ml.IHC: |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20Β°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TLE5 |
| Gene ID | 166 |
| Uniprot ID | TLE5_HUMAN |
| Accession Number | NP_945320.1; NP_001121.2; NP_945321.1 |
| Immunogen Region | N-Term |
| Immunogen Sequence | SHLPQQLKFTTSD |
| Specificity | This antibody is expected to recognize all reported isoforms (NP_945320.1; NP_001121.2; NP_945321.1). |
Additional Info
| Post Translational Modifications | Ubiquitinated by XIAP/BIRC4. |
| Function | Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. |
| Protein Name | Tle Family Member 5Amino-Terminal Enhancer Of SplitAmino Enhancer Of SplitGp130-Associated Protein GamGrg-5Groucho-Related Protein 5Protein Esp1Protein GrgTle Family Member 5 - Transcriptional Modulator |
| Database Links | Reactome: R-HSA-4641265 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Tle Family Member 5 antibodyAnti-Amino-Terminal Enhancer Of Split antibodyAnti-Amino Enhancer Of Split antibodyAnti-Gp130-Associated Protein Gam antibodyAnti-Grg-5 antibodyAnti-Groucho-Related Protein 5 antibodyAnti-Protein Esp1 antibodyAnti-Protein Grg antibodyAnti-Tle Family Member 5 - Transcriptional Modulator antibodyAnti-TLE5 antibodyAnti-AES antibodyAnti-GRG antibodyAnti-GRG5 antibody |
Information sourced from Uniprot.org