Anti-ADSL antibody (1-484 aa) [SRM5256] (STJ11107158)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ADSL (1-484 aa) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5256 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADSL |
| Gene ID | 158 |
| Uniprot ID | PUR8_HUMAN |
| Immunogen Region | 1-484 aa |
| Immunogen Sequence | MAAGGDHGSPDSYRSPLASR YASPEMCFVFSDRYKFRTWR QLWLWLAEAEQTLGLPITDE QIQEMKSNLENIDFKMAAEE EKRLRHDVMAHVHTFGHCCP KAAGIIHLGATSCYVGDNTD LIILRNALDLLLPKLARVIS RLADFAKERASLPTLGFTHF QPAQLTTVGKRCCLWIQDLC MDLQNLKRVRDDLRFRGVKG TTGTQASFLQLFEGDDHKVE QLDKMVTEKAGFKRAFIIT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-484 of human ADSL (NP_000017.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1. |
| Function | Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
| Protein Name | Adenylosuccinate LyaseAdslAslAdenylosuccinaseAsase |
| Database Links | Reactome: R-HSA-73817 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Adenylosuccinate Lyase antibodyAnti-Adsl antibodyAnti-Asl antibodyAnti-Adenylosuccinase antibodyAnti-Asase antibodyAnti-ADSL antibodyAnti-AMPS antibody |
Information sourced from Uniprot.org