Anti-ADRA2B antibody (1-100) (STJ111276)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADRA2B (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADRA2B |
| Gene ID | 151 |
| Uniprot ID | ADA2B_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MDHQDPYSVQATAAIAAAIT FLILFTIFGNALVILAVLTS RSLRAPQNLFLVSLAAADIL VATLIIPFSLANELLGYWYF RRTWCEVYLALDVLFCTSSI |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRA2B (NP_000673.2). |
Additional Info
| Function | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. |
| Protein Name | Alpha-2b Adrenergic ReceptorAlpha-2 Adrenergic Receptor Subtype C2Alpha-2b AdrenoreceptorAlpha-2b AdrenoceptorAlpha-2bar |
| Database Links | Reactome: R-HSA-390696Reactome: R-HSA-392023Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInteraction With Rab26Gga1Gga2 And Gga3 Mediates Transport From The Golgi To The Cell Membrane |
| Alternative Antibody Names | Anti-Alpha-2b Adrenergic Receptor antibodyAnti-Alpha-2 Adrenergic Receptor Subtype C2 antibodyAnti-Alpha-2b Adrenoreceptor antibodyAnti-Alpha-2b Adrenoceptor antibodyAnti-Alpha-2bar antibodyAnti-ADRA2B antibodyAnti-ADRA2L1 antibodyAnti-ADRA2RL1 antibody |
Information sourced from Uniprot.org