Anti-ADIPOR1 antibody (1-136) (STJ118954)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Adiponectin Receptor 1 (1-136) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADIPOR1 |
| Gene ID | 51094 |
| Uniprot ID | PAQR1_HUMAN |
| Immunogen Region | 1-136 |
| Immunogen Sequence | MSSHKGSVVAQGNGAPASNR EADTVELAELGPLLEEKGKR VIANPPKAEEEQTCPVPQEE EEEVRVLTLPLQAHHAMEKM EEFVYKVWEGRWRVIPYDVL PDWLKDNDYLLHGHRPPMPS FRACFKSIFRIHTETG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-136 of human Adiponectin Receptor 1 (NP_057083.2). |
Additional Info
| Tissue Specificity | Widely expressed. Highly expressed in heart and skeletal muscle. Expressed at intermediate level in brain, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine. |
| Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. |
| Protein Name | Adiponectin Receptor Protein 1Progestin And Adipoq Receptor Family Member 1Progestin And Adipoq Receptor Family Member I |
| Database Links | Reactome: R-HSA-163680 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Cell Membrane And Intracellular Organelles |
| Alternative Antibody Names | Anti-Adiponectin Receptor Protein 1 antibodyAnti-Progestin And Adipoq Receptor Family Member 1 antibodyAnti-Progestin And Adipoq Receptor Family Member I antibodyAnti-ADIPOR1 antibodyAnti-PAQR1 antibodyAnti-TESBP1A antibodyAnti-CGI-45 antibody |
Information sourced from Uniprot.org